Question
Download Solution PDFWhat do you mean by semiconservative DNA replication?
Answer (Detailed Solution Below)
Detailed Solution
Download Solution PDFKey Points
- Semiconservative DNA replication means that after the completion of replication, each DNA molecule consists of one parental (original) strand and one newly synthesized strand.
- This model of DNA replication was first proposed by Watson and Crick in 1953 and later confirmed by the Meselson-Stahl experiment in 1958.
- The semiconservative nature ensures genetic consistency through generations, as each new DNA molecule retains one strand from the original DNA.
- This mechanism is crucial for the accurate transmission of genetic information during cell division.
Additional Information
- DNA replication is a fundamental process that occurs in all living organisms to copy their DNA, allowing for cell division and reproduction.
- There are three main hypotheses for DNA replication: conservative, semiconservative, and dispersive. The semiconservative model is the one that has been experimentally validated.
- In the Meselson-Stahl experiment, E. coli bacteria were grown in a medium containing a heavy isotope of nitrogen (15N) and then transferred to a medium with a lighter isotope (14N). The results showed that after one round of replication, the DNA consisted of hybrid molecules (one strand 15N and one strand 14N), supporting the semiconservative model.
- This process ensures that the genetic material is accurately duplicated and passed on to daughter cells, maintaining the integrity of the genome.
Last updated on May 28, 2025
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