Which of the following drugs is associated with the reaction of Stevens-Johnson syndrome?

Question

Question

Answer 1

Correct Answer: Valproic acid

Rationale:

Stevens-Johnson syndrome (SJS) is a rare, serious disorder of the skin and mucous membranes. It is often a reaction to a medication or an infection and typically begins with flu-like symptoms followed by a painful red or purplish rash that spreads and blisters.
Valproic acid, an antiepileptic drug, has been associated with severe skin reactions such as Stevens-Johnson syndrome. This adverse effect, although rare, can be life-threatening and requires immediate medical attention.
Patients on valproic acid who develop skin reactions should be evaluated promptly to rule out SJS, and the medication should be discontinued if this condition is suspected.

Explanation of Other Options:

Quinidine

Rationale: Quinidine is an antiarrhythmic medication used to treat certain types of irregular heartbeat. While it has its own set of potential side effects, it is not commonly associated with Stevens-Johnson syndrome.

Isoniazid

Rationale: Isoniazid is an antibiotic used for the treatment and prevention of tuberculosis. Although it has potential side effects including liver toxicity and peripheral neuropathy, SJS is not a common reaction associated with this drug.

Procainamide

Rationale: Procainamide is another antiarrhythmic drug used to treat abnormal heart rhythms. Similar to quinidine, while it has various side effects including drug-induced lupus erythematosus, it is not primarily linked to Stevens-Johnson syndrome.

Conclusion:

Among the given options, valproic acid is the drug most commonly associated with Stevens-Johnson syndrome. Recognizing the symptoms early and discontinuing the medication can be critical in managing this potentially life-threatening condition.